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Enzymatic Racemisation and its Application to Synthetic Biotransformations
Author(s) -
Schnell Barbara,
Faber Kurt,
Kroutil Wolfgang
Publication year - 2003
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303009
Subject(s) - kinetic resolution , chemistry , biocatalysis , enantiomer , context (archaeology) , substrate (aquarium) , organic chemistry , biochemical engineering , product inhibition , resolution (logic) , enantiomeric excess , stereochemistry , enantioselective synthesis , enzyme , combinatorial chemistry , reaction mechanism , catalysis , paleontology , oceanography , non competitive inhibition , artificial intelligence , geology , computer science , engineering , biology
In contrast to kinetic resolution, where only 50% of the racemic starting material can be converted into the desired product and where the remaining ‘wrong' enantiomer has to be considered as waste, so‐called deracemisation processes allow the production of a single stereoisomeric product from racemic starting material. In this context, the use of environmentally benign methods for biocatalytic racemisation holds great potential. The small and largely overlooked group of racemases (EC 5.1.X.X), which are increasingly being used for dynamic kinetic resolution or in auxiliary biocatalytic recycling processes, are reviewed with respect to their properties, their substrate tolerance and their biocatalytic potential.