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Recent Advances in Asymmetric CC and C‐Heteroatom Bond Forming Reactions using Polymer‐Bound Catalysts
Author(s) -
Bräse Stefan,
Lauterwasser Frank,
Ziegert Robert E.
Publication year - 2003
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200202164
Subject(s) - chemistry , enantioselective synthesis , heteroatom , catalysis , aldol reaction , cycloaddition , organic synthesis , dendrimer , combinatorial chemistry , organic chemistry , reagent , organocatalysis , organic reaction , polymer chemistry , ring (chemistry)
Abstract The synthesis of enantiomerically pure compounds is one of the major challenges in organic synthesis. In this review, we present the state of the art in asymmetric catalysis using immobilized chiral ligands and complexes for asymmetric CC and C‐heteroatom bond forming reactions. Chiral catalysts based on dendrimers and soluble polymeric supports are considered. In particular, addition reactions to carbon‐carbon double bonds, asymmetric 1,2‐addition reactions using, e.g., dialkylzinc reagents, metal‐catalyzed substitution reactions and cycloaddition reactions are covered. Specific emphasis is placed on enantioselective epoxidation and aldol reactions. A further aspect is the (hetero) Diels–Alder reaction catalyzed by immobilized ligands.