Open AccessOn‐Chip Optical Detection of Viruses: A Review
Author(s) -
Shi Yuzhi,
Li Zhenyu,
Liu Patricia Yang,
Nguyen Binh Thi Thanh,
Wu Wenshuai,
Zhao Qianbin,
Chin Lip Ket,
Wei Minggui,
Yap Peng Huat,
Zhou Xiaohong,
Zhao Hongwei,
Yu Dan,
Tsai Din Ping,
Liu Ai Qun
Publication year - 2021
Publication title -
advanced photonics research
Language(s) - English
Resource type - Journals
ISSN - 2699-9293
DOI - 10.1002/adpr.202000150
Subject(s) - chip , virology , computer science , biology , telecommunications
The current outbreak of the coronavirus disease‐19 (COVID‐19) pandemic worldwide has caused millions of fatalities and imposed a severe impact on our daily lives. Thus, the global healthcare system urgently calls for rapid, affordable, and reliable detection toolkits. Although the gold‐standard nucleic acid amplification tests have been widely accepted and utilized, they are time‐consuming and labor‐intensive, which exceedingly hinder the mass detection in low‐income populations, especially in developing countries. Recently, due to the blooming development of photonics, various optical chips have been developed to detect single viruses with the advantages of fast, label‐free, affordable, and point of care deployment. Herein, optical approaches especially in three perspectives, e.g., flow‐free optical methods, optofluidics, and surface‐modification‐assisted approaches, are summarized. The future development of on‐chip optical‐detection methods in the wave of emerging new ideas in nanophotonics is also briefly discussed.