z-logo
Premium
Facile Microfluidic Fabrication of 3D Hydrogel SERS Substrate with High Reusability and Reproducibility via Programmable Maskless Flow Microlithography
Author(s) -
Shin Yoonkyung,
Jeon Inkyu,
You Younghoon,
Song Gwangho,
Lee Tae Kyung,
Oh Jongwon,
Son Changil,
Baek Dahye,
Kim Dowon,
Cho Heesu,
Hwang Hyeri,
Kim Taeyoung,
Kwak Sang Kyu,
Kim Jungwook,
Lee Jiseok
Publication year - 2020
Publication title -
advanced optical materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 91
ISSN - 2195-1071
DOI - 10.1002/adom.202001586
Subject(s) - materials science , nanotechnology , microfluidics , reusability , analyte , substrate (aquarium) , fabrication , self healing hydrogels , surface modification , reproducibility , surface enhanced raman spectroscopy , raman scattering , raman spectroscopy , chemical engineering , computer science , chemistry , optics , physics , alternative medicine , software , oceanography , pathology , chromatography , programming language , medicine , geology , engineering , polymer chemistry
In the field of surface‐enhanced Raman scattering (SERS), advances in nanotechnology and surface chemistry have contributed to fabricating the metal substrates with highly sophisticated architectures and strong binding affinity to target molecules which enhanced the sensitivity to target molecules. However, the elaborate yet complicated steps for the synthesis, patterning, and surface modification of metal substrates have often resulted in compromising the reliability, reproducibility, and reusability as SERS substrates. Here, a fully programmable and automated digital maskless flow microlithography process that spatiotemporally controls the fluid flow, UV irradiation, and the shape and location of SERS polymer matrix is provided to fabricate a reliable, reproducible, and reusable hydrogel‐based 3D SERS substrate. The SERS substrates are located inside the microfluidic device in the form of disk‐shaped hydrogels. By rationally designing the functional group chemistry of the hydrogel microposts, Ag nanoparticles are homogeneously synthesized in situ, a target molecule is amplified by 25‐fold inside the microposts, and an enhancement factor as high as 2.4 × 10 8 is observed. Furthermore, a highly reusable multitarget sensing capability is demonstrated by a sequential analysis of multiple analytes without the trace of former analytes via the intermittent washing step.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here