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Plasmonic Detection of Carbohydrate‐Mediated Biological Events
Author(s) -
García Isabel,
Mosquera Jesús,
Plou Javier,
LizMarzán Luis M.
Publication year - 2018
Publication title -
advanced optical materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 91
ISSN - 2195-1071
DOI - 10.1002/adom.201800680
Subject(s) - nanotechnology , biosensor , biomolecule , plasmon , nanomaterials , glycomics , materials science , surface plasmon resonance , glycan , nanosensor , bioanalysis , raman scattering , plasmonic nanoparticles , nanoparticle , raman spectroscopy , chemistry , optoelectronics , optics , glycoprotein , biochemistry , physics
The incorporation of nanomaterials in glycoscience research enables the design of highly selective and sensitive bioanalytical devices for the detection of disease‐associated biomarkers. In particular, localized surface plasmon resonance (LSPR) and surface enhanced Raman scattering (SERS) spectroscopies are powerful biosensing techniques that employ metallic nanostructures to achieve efficient detection of biomolecules. Herein, the most recent achievements are reviewed toward the use of plasmonic nanomaterials together with glycans or glycan‐interacting moieties, to detect carbohydrate‐mediated biological interactions. The review thus focuses on the use of novel optical nanosensors, mainly LSPR and SERS, for the detection of saccharides, lectins, viruses, bacteria, and even whole eukaryotic cells.