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Unprecedentedly High Tissue Penetration Capability of Co‐Assembled Nanosystems for Two‐Photon Fluorescence Imaging In Vivo
Author(s) -
Yang PeiPei,
Yang Yang,
Gao YuJuan,
Wang Yi,
Zhang JuChen,
Lin YaoXin,
Dai Luru,
Li Junbai,
Wang Lei,
Wang Hao
Publication year - 2015
Publication title -
advanced optical materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 91
ISSN - 2195-1071
DOI - 10.1002/adom.201400522
Subject(s) - förster resonance energy transfer , fluorescence , materials science , nanotechnology , energy transfer , photon , near infrared spectroscopy , contrast (vision) , penetration depth , fluorophore , fluorescence lifetime imaging microscopy , two photon excitation microscopy , computer science , optoelectronics , optics , engineering physics , artificial intelligence , physics
The current challenge in two‐photon fluorescence for biomedical imaging is to develop extremely bright contrast agents with long wavelength emission. A Förster resonance energy transfer‐based supramolecular nanosystem via co‐assembly strategy, capable of achieving the modulation of emission wavelength to near‐infrared (NIR) range upon two‐photon NIR irradiation, is introduced as a highly emissive and photo‐stable contrast agent for deep tissue two‐photon fluorescence imaging in vivo.