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Targeted Chemotherapy: Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump (Adv. Mater. Technol. 5/2021)
Author(s) -
Waldherr Linda,
Seitanidou Maria,
Jakešová Marie,
Handl Verena,
Honeder Sophie,
Nowakowska Marta,
Tomin Tamara,
Karami Rad Meysam,
Schmidt Tony,
Distl Joachim,
BirnerGruenberger Ruth,
Campe Gord,
Schäfer Ute,
Berggren Magnus,
Rinner Beate,
Asslaber Martin,
GhaffariTabriziWizsy Nassim,
Patz Silke,
Simon Daniel T.,
Schindl Rainer
Publication year - 2021
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.202170026
Subject(s) - gemcitabine , chemotherapy , glioblastoma , materials science , drug delivery , cancer research , nanotechnology , glioma , oncology , biomedical engineering , medicine
In article number 2001302, Silke Patz, Daniel T. Simon, Rainer Schindl, and co‐workers engineer an electronically‐driven ion pump for the targeted delivery of the charged chemotherapeutic gemcitabine to brain cancer cells. By delivering drug ions over a cation exchange membrane at currents in the nanoampere range, brain cancer cell death and microtumor disintegration is triggered. This local gemcitabine treatment offers a therapeutical window, in contrast to standard treatment.