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Conducting Polymer‐Based Granular Hydrogels for Injectable 3D Cell Scaffolds
Author(s) -
Feig Vivian Rachel,
Santhanam Sruthi,
McConnell Kelly Wu,
Liu Kathy,
Azadian Matine,
Brunel Lucia Giulia,
Huang Zhuojun,
Tran Helen,
George Paul M.,
Bao Zhenan
Publication year - 2021
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.202100162
Subject(s) - self healing hydrogels , materials science , biocompatibility , scaffold , tissue engineering , nanotechnology , polymer , biomedical engineering , composite material , polymer chemistry , medicine , metallurgy
Injectable 3D cell scaffolds possessing both electrical conductivity and native tissue‐level softness would provide a platform to leverage electric fields to manipulate stem cell behavior. Granular hydrogels, which combine jamming‐induced elasticity with repeatable injectability, are versatile materials to easily encapsulate cells to form injectable 3D niches. In this work, it is demonstrated that electrically conductive granular hydrogels can be fabricated via a simple method involving fragmentation of a bulk hydrogel made from the conducting polymer PEDOT:PSS. These granular conductors exhibit excellent shear‐thinning and self‐healing behavior, as well as record‐high electrical conductivity for an injectable 3D scaffold material (≈10 S m −1 ). Their granular microstructure also enables them to easily encapsulate induced pluripotent stem cell (iPSC)‐derived neural progenitor cells, which are viable for at least 5 d within the injectable gel matrices. Finally, gel biocompatibility is demonstrated with minimal observed inflammatory response when injected into a rodent brain.