Premium
Microfluidic Devices: High‐Throughput Separation of Microvesicles from Whole Blood Components Using Viscoelastic Fluid (Adv. Mater. Technol. 12/2020)
Author(s) -
Nam Jeonghun,
Yoon Jung,
Jee Hyunseul,
Jang Woong Sik,
Lim Chae Seung
Publication year - 2020
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.202070071
Subject(s) - microvesicles , microfluidics , whole blood , isolation (microbiology) , platelet , materials science , nanotechnology , biomedical engineering , chemistry , medicine , immunology , biology , bioinformatics , microrna , biochemistry , gene
In article number 2000612, Jeonghun Nam, Chae Seung Lim, and co‐workers demonstrate a sheathless, label‐free, viscoelastic microfluidic device for separation of submicrometer microvesicles (MVs) from whole blood. This device enables the isolation of platelet‐derived microparticles (PDMPs) from diluted whole blood sample without platelet activation. It can be expected that the device can be used as a standard protocol, enabling high‐recovery and high‐sensitivity isolation of MVs shed from not only blood cells, but also bacteria, viruses, or cancer, for disease diagnosis in clinical settings.