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Microfluidic Systems: A 3D Biohybrid Real‐Scale Model of the Brain Cancer Microenvironment for Advanced In Vitro Testing (Adv. Mater. Technol. 10/2020)
Author(s) -
Tricinci Omar,
De Pasquale Daniele,
Marino Attilio,
Battaglini Matteo,
Pucci Carlotta,
Ciofani Gianni
Publication year - 2020
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.202070063
Subject(s) - microfluidics , glioblastoma , spheroid , in vitro , u87 , parenchyma , blood–brain barrier , 3d printed , tumor microenvironment , biomedical engineering , brain cancer , cancer research , nanotechnology , chemistry , cancer , neuroscience , materials science , pathology , medicine , biology , tumor cells , central nervous system , biochemistry
In article number 2000540, Omar Tricinci, Daniele De Pasquale, Attilio Marino, Gianni Ciofani, and co‐workers present a real‐scale 3D‐printed biohybrid microfluidic device that can mimic the glioblastoma microenvironment at the level of the blood–brain barrier, with both luminal and parenchyma compartments. It allows the triple co‐culture of endothelial cells, astrocytes, and magnetically‐driven spheroids of U87 glioblastoma cells. The device demonstrates to be successfully exploitable as a realistic in vitro model for high‐throughput drug screening.