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A One‐Step Biofunctionalization Strategy of Electrospun Scaffolds Enables Spatially Selective Presentation of Biological Cues
Author(s) -
Wieringa Paul,
Girao Andre,
Ahmed Maqsood,
TruckenmÜller Roman,
Welle Alexander,
Micera Silvestro,
Wezel Richard,
Moroni Lorenzo
Publication year - 2020
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.202000269
Subject(s) - materials science , biomimetics , nanotechnology , regenerative medicine , extracellular matrix , surface modification , tissue engineering , biomedical engineering , chemical engineering , cell , chemistry , biochemistry , engineering , medicine
To recapitulate the heterogeneous complexity of tissues in the human body with synthetic mimics of the extracellular matrix (ECM), it is important to develop methods that can easily allow the selective functionalization of defined spatial domains. Here, a facile method is introduced to functionalize microfibrillar meshes with different reactive groups able to bind biological moieties in a one‐step reaction. The resulting scaffolds prove to selectively support a differential neurite growth after being seeded with dorsal root ganglia. Considering the general principles behind the method developed, this is a promising strategy to realize enhanced biomimicry of native ECM for different regenerative medicine applications.