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Biomimetic Gradient: A Microfluidic Model with Hydrogel Barriers for the Construction of Shear‐Free Attractive and Repulsive Cue Gradients (Adv. Mater. Technol. 2/2019)
Author(s) -
Liu Wenming,
Han Kai,
Sun Meilin,
Huang Zhongchao,
Wang Jinyi
Publication year - 2019
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.201970013
Subject(s) - microfluidics , concentration gradient , nanotechnology , materials science , biomimetics , microfluidic chip , self healing hydrogels , shear (geology) , engineering , composite material , biochemical engineering , polymer chemistry
A microfluidic approach for the integration of multiple biochemical concentration gradients in a single microfluidic device is presented in article number 1800434 , by Wenming Liu, Jinyi Wang, and co‐workers. The employment of multidirectional hydrogel barriers permits a facile, stable, and long‐term microfluidic production of shear‐free single and double biochemical gradients. Multi‐gradient microfluidics provides a prototypical platform to perform on‐chip biomimetic neuronal manipulation and analysis for the exploration of neurogenesis and development as well as neuro‐regeneration.