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Localizing Seizure Activity in the Brain Using Implantable Micro‐LEDs with Quantum Dot Downconversion
Author(s) -
Choi Christopher,
ColónBerríos Aida R.,
Hamachi Leslie S.,
Owen Jonathan S.,
Schwartz Theodore H.,
Ma Hongtao,
Kymissis Ioannis
Publication year - 2018
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.201700366
Subject(s) - light emitting diode , optoelectronics , materials science , quantum dot , substrate (aquarium) , electrode , photoluminescence , neural activity , epilepsy , biomedical engineering , medicine , neuroscience , chemistry , psychology , oceanography , geology
Current methods for high resolution imaging of neural activity, such as functional magnetic resonance imaging and penetrating electrode arrays, are not well suited for chronic patient monitoring in clinical settings. The ability to locally monitor neural activity in the brain would benefit doctors and surgeons treating and diagnosing neurological diseases such as epilepsy. Measurement of the intrinsic optical signal offers a high resolution (better than 100 µm) for the localization of brain activity. The localized detection of seizures in rats using an implantable optical sensor is demonstrated. The implantable optical sensor is fabricated on a 25 µm thick, flexible polyimide substrate and uses micro‐LEDs to measure localized changes in reflectivity due to cerebral blood flow when attached to the surface of the brain. Quantum dot coatings are applied directly to the micro‐LEDs via pneumatic printing for wavelength conversion by photoluminescent re‐emission.