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Tissue Engineering: Defined Micropatterning of ECM Protein Adhesive Sites on Alginate Microfibers for Engineering Highly Anisotropic Muscle Cell Bundles (Adv. Mater. Technol. 4/2016)
Author(s) -
Patil Prarthana,
Szymanski John M.,
Feinberg Adam W.
Publication year - 2016
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.201670021
Subject(s) - micropatterning , microfiber , c2c12 , extracellular matrix , materials science , fibronectin , adhesive , tissue engineering , skeletal muscle , biomedical engineering , anatomy , nanotechnology , chemistry , composite material , myogenesis , engineering , biology , biochemistry , layer (electronics)
Adam W. Feinberg and co‐workers present in article number 1600003 a method to engineer alginate microfibers with precisely defined micropatterning of extracellular matrix (ECM) protein adhesive sites. The upper part of the cover image shows a muscle fiber bundle composed of multiple alginate microfibers that together form a structure similar to the in vivo architecture of skeletal muscle. The lower part shows multiple alginate microfibers patterned with fibronectin adhesive sites direct the uniaxial alignment of C2C12 skeletal muscle myoblasts.