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Defined Micropatterning of ECM Protein Adhesive Sites on Alginate Microfibers for Engineering Highly Anisotropic Muscle Cell Bundles
Author(s) -
Patil Prarthana,
Szymanski John M.,
Feinberg Adam W.
Publication year - 2016
Publication title -
advanced materials technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.184
H-Index - 42
ISSN - 2365-709X
DOI - 10.1002/admt.201600003
Subject(s) - micropatterning , microfiber , materials science , adhesion , adhesive , ribbon , tissue engineering , nanotechnology , composite material , biomedical engineering , engineering , layer (electronics)
A process is developed to engineer hydrogel microfibers with precise micropatterning of ECM protein adhesive sites in order to control the adhesion, spreading, and alignment of muscle cells. Uniquely, the ribbon‐like microfibers wrap around the cells, aiding in uniaxial alignment and enabling the formation of multifiber bundles to form larger anisotropic skeletal muscle tissue.