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Biomaterials: Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy (Adv. Mater. Interfaces 19/2020)
Author(s) -
Cheng YinJia,
Qin SiYong,
Liu WenLong,
Ma YiHan,
Chen XiaoSui,
Zhang AiQing,
Zhang XianZheng
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.202070108
Subject(s) - photosensitizer , protoporphyrin ix , photodynamic therapy , conjugate , amphiphile , drug delivery , doxorubicin , peptide , cytotoxicity , materials science , cancer research , biophysics , chemistry , nanotechnology , biochemistry , chemotherapy , medicine , in vitro , biology , copolymer , photochemistry , organic chemistry , mathematical analysis , mathematics , composite material , polymer
In article number 2000935, Yin‐Jia Cheng, Xian‐Zheng Zhang and co‐workers successfully prepared a photosensitizer‐peptide amphiphile conjugate, which displays specific cellular uptake by tumor cells, and directly delivers doxorubicin to nucleus and protoporphyrin IX to mitochondria. The nanosystem can significantly maximize the therapeutic effect against tumor cells with minimal off‐target cytotoxicity, thus holding great potential for enhanced chemo‐photodynamic tumor therapy.