Premium
Poly(methyl methacrylate): Covalent Functionalization of PMMA Surface with L‐3,4‐Dihydroxyphenylalanine (L‐DOPA) to Enhance its Biocompatibility and Adhesion to Corneal Tissue (Adv. Mater. Interfaces 1/2020)
Author(s) -
Sharifi Roholah,
Mahmoudzadeh Soudabe,
Islam Mohammad Mirazul,
Koza Darrell,
Dohlman Claes H.,
Chodosh James,
GonzalezAndrades Miguel
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.202070001
Subject(s) - biocompatibility , dihydroxyphenylalanine , materials science , surface modification , keratoprosthesis , adhesion , methacrylate , methyl methacrylate , poly(methyl methacrylate) , covalent bond , cornea , biomedical engineering , polymer chemistry , chemical engineering , nanotechnology , composite material , ophthalmology , polymer , organic chemistry , chemistry , medicine , copolymer , dopamine , engineering , metallurgy , endocrinology
Poly(methyl methacrylate) (PMMA) surface is covalently functionalized with L‐3,4‐dihydroxyphenylalanine (L‐DOPA) to form stable coating that significantly improves the biocompatibility of the PMMA. L‐DOPA‐functionalized PMMA also preserves the phenotypic characteristics of corneal fibroblast, supporting cellular adhesion, proliferation, and migration, which may lead to better biointegration of the Boston keratoprosthesis, the most commonly implanted artificial cornea for patients with severe corneal diseases. More details can be found in article number 1900767 by James Chodosh, Miguel Gonzalez‐Andrades, and co‐workers.