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Fabrication of Citric Acid/RGD Multilayers on Mg‐Zn‐Y‐Nd Alloy via Layer‐by‐Layer Self‐Assembly for Promoting Surface Biocompatibility
Author(s) -
Kou Fang,
Liu Changsheng,
Wang Liguo,
Yasin Aqeela,
Li Jingan,
Guan Shaokang
Publication year - 2021
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.202002241
Subject(s) - materials science , biocompatibility , citric acid , surface modification , layer (electronics) , adhesion , umbilical vein , simulated body fluid , chemical engineering , hydrofluoric acid , biomolecule , nanotechnology , composite material , metallurgy , organic chemistry , chemistry , biochemistry , engineering , scanning electron microscope , in vitro
Magnesium (Mg) alloy, an important biodegradable material widely investigated on cardiovascular stent, is restricted for further application due to some limited functions, such as the excessively rapid degradation rate, poor hemocompatibility, and delayed re‐endothelialization. To overcome these shortcomings, surface modification with biomolecules has attracted much attention. In this study, the multifunctional coatings of citric acid (CA) and Arg‐Gly‐Asp (RGD) via layer‐by‐layer self‐assembly are immobilized onto the polydopamine (PDA) deposited surface which is passivated with hydrofluoric acid (HF) solution before. The basic characterization results suggest that PDA/(CA‐RGD) 2 coating exhibits a rich‐in‐amine and hydrophilic surface. The corrosion current density of PDA/(CA‐RGD) 2 exposed to simulated body fluid is reduced by 95.65% from 1.586 × 10 −4 to 6.894 × 10 −6 A cm −2 under the protection of the dense MgF 2 layer and multifunctional coatings. Besides, inhibition on platelet adhesion, hemolysis rates, and fibrinogen adsorption also prove the enhanced hemocompatibility of the PDA/(CA‐RGD) 2 coatings. Meanwhile, the human umbilical vein endothelial cells (HUVECs) and smooth muscle cells (SMCs) culture results jointly prove the excellent endothelialization performance of functionalized samples. In conclusion, the above mentioned results reveal that the functionalized surface of PDA/(CA‐RGD) 2 displays better overall performance, indicating a preferable application for cardiovascular stents.