Premium
Fabrication of Biopassive Surfaces Using Poly(2‐alkyl‐2‐oxazoline)s: Recent Progresses and Applications
Author(s) -
Trachsel Lucca,
Romio Matteo,
Ramakrishna Shivaprakash N.,
Benetti Edmondo M.
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.202000943
Subject(s) - materials science , oxazoline , nanotechnology , ethylene glycol , surface modification , nanomedicine , nanomaterials , passivation , alkyl , fabrication , nanoparticle , chemical engineering , organic chemistry , chemistry , medicine , alternative medicine , layer (electronics) , pathology , engineering , catalysis
Poly(2‐alkyl‐2‐oxazoline)s (PAOXAs) are emerging among the most promising nonionic alternatives to poly(ethylene glycol)s (PEGs), specifically in the modification and functionalization of biomaterials. Due to their chemical tailorability and robustness, coupled to their relatively easy synthesis, PAOXAs are increasingly applied as adsorbates to generate bioinert surfaces that prevent nonspecific contamination by proteins, cells and bacteria. Passivation of medical devices, sensors and cell‐sensitive platforms with PAOXAs enables a nearly quantitative suppression of nonspecific biological contamination, while biopassivity is maintained over longer incubation times than those recorded for more degradable PEG‐based coatings. Thanks to these unique advantages, surface modification strategies involving PAOXAs are expanding to nanomaterials, especially those applied in the fabrication of nanomedicine and bioimaging tools.