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Surface‐Initiated Grafting of Dendritic Polyglycerol from Mussel‐Inspired Adhesion‐Layers for the Creation of Cell‐Repelling Coatings
Author(s) -
Kulka Michaël W.,
Nie Chuanxiong,
Nickl Philip,
Kerkhoff Yannic,
Garg Arushi,
Salz Dirk,
Radnik Jörg,
Grunwald Ingo,
Haag Rainer
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.202000931
Subject(s) - grafting , materials science , x ray photoelectron spectroscopy , contact angle , polydimethylsiloxane , scanning electron microscope , biofouling , adhesion , chemical engineering , adhesive , surface roughness , surface modification , titanium , polymer chemistry , nanotechnology , composite material , chemistry , polymer , layer (electronics) , biochemistry , membrane , engineering , metallurgy
Biofouling is a major challenge in the application of textiles, biosensors, and biomedical implants. In the current work, a straightforward method for the solvent‐free polymerization of antifouling dendritic polyglycerol (dPG) from mussel‐inspired dendritic polyglycerol (MI‐dPG) coatings on hydrophilic titanium dioxide (TiO 2 ) and hydrophobic polydimethylsiloxane (PDMS) is reported. Surface characterization is performed by static water contact angle (CA) measurements, X‐ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Significant lower CA values are obtained after dPG grafting from MI‐dPG‐coated TiO 2 and MI‐dPG coated PDMS. Furthermore, XPS shows a time‐dependent increase of the CO bond content upon dPG grafting from MI‐dPG‐coated TiO 2 and MI‐dPG‐coated PDMS. Analysis of the surface morphology by SEM shows a clear time‐dependent increase in the surface roughness upon dPG grafting from MI‐dPG‐coated TiO 2 and MI‐dPG‐coated PDMS. When the viability of two adhesive cell types is studied via LIVE/DEAD staining, a strong reduction in the cell density is observed after the dPG grafting from MI‐dPG‐coated TiO 2 and MI‐dPG‐coated PDMS (a decrease of >95% in all cases). The combined results show that biocompatible but highly cell‐repelling surfaces are efficiently constructed via the grafting of dPG from MI‐dPG‐coated TiO 2 and MI‐dPG‐coated PDMS.