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Photoactive Metal–Organic Framework@Porous Organic Polymer Nanocomposites with pH‐Triggered Type I Photodynamic Therapy
Author(s) -
Liu Wan,
Chen Li,
Wang Lei,
Xie Zhigang
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.202000504
Subject(s) - nanoporous , photodynamic therapy , materials science , hela , nanocomposite , polymer , metal organic framework , porosity , chemical engineering , nanotechnology , chemistry , organic chemistry , composite material , adsorption , biochemistry , cell , engineering
Photodynamic therapy (PDT) is a promising treatment for cancer, but the hypoxic tumor microenvironment limits its therapeutic effect, especially in these oxygen‐dependent PDT‐II systems. Herein, a nanoporous MOF@POP composite, named UBP, is synthesized by template strategy to effectively integrate BODIPY‐contained porous organic polymers (POP) and MOF within one system. Such UBP possesses well dispersibility and pH‐triggered type I photodynamic performance, which shows a selected toxicity to cancer cells (HeLa cells) but less damage to normal cells (L929 cells).