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Bifunctional Nanomaterials for Enhanced Cell Proliferation and for the Reduction of Bacterial Bioluminescence/Fitness
Author(s) -
Motealleh Andisheh,
Czieborowski Michael,
Philipp Bodo,
Nowak Sascha,
Kehr Nermin S.
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.202000086
Subject(s) - bifunctional , nanomaterials , materials science , bioluminescence , cell growth , nanotechnology , bacterial growth , bacterial cell structure , mesoporous material , cell , biophysics , bacteria , chemistry , catalysis , biochemistry , biology , genetics
This study describes the synthesis of bifunctional nanomaterials that can both inhibit bacterial bioluminescence, an indicator for the bacterial fitness, and, simultaneously, improve the proliferation of eukaryotic cells, a property that is desired for biomedical devices such as implants. To prepare this functional nanomaterial, the pores of the periodic mesoporous organosilica (PMO) nanocontainers are first functionalized with dexamethasone (Dex), which has anti‐inflammatory and cell proliferation properties. Then, the external surface of the PMO is functionalized with the antibacterial and cell adhesive bipolymer poly‐ d ‐lysine (PDL). The results show that cofunctionalization of the PMO surfaces with both Dex and PDL have beneficial additive and/or synergistic effects on cell proliferation and bacterial bioluminescence inhibition.