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Controlling Preosteoblast Behavior through Manganese Vacancy‐Rich Birnessite with Enhanced Divalent Cation Modulation of Fibronectin–Integrin Interactions
Author(s) -
Liu Shiwei,
Li Kai,
Hu Tao,
Wu Xiaodong,
Ao Haiyong,
Xie Youtao,
Zheng Xuebin
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201902127
Subject(s) - birnessite , divalent , adsorption , fibronectin , materials science , manganese , ligand (biochemistry) , aqueous solution , inorganic chemistry , biophysics , chemistry , receptor , biochemistry , cell , metallurgy , biology , organic chemistry , manganese oxide
The osteoblast‐function associated integrin–ligand interactions are known to be dependent on divalent cations, but there is scarce information about the effect of Ca 2+ and Mg 2+ adsorption properties of an implant surface on integrin α 5 β 1 –fibronectin interactions and the subsequent osteoblast behavior. Cation adsorption properties are closely associated with the extent of structural defects in materials. Here, the birnessite‐type MnO 2 coatings with different amounts of manganese vacancy ( V Mn ) are prepared on Ti substrates via hydrothermal treatment (denoted as 1M100‐Ti, 5M100‐Ti, and 5M120‐Ti). The 5M120‐Ti surface with hierarchical flower‐like structure and the most stacked [MnO 6 ] layers possess the highest V Mn content, which is determined by the ratios of Mn 3+ /Mn 4+ and K/Mn. The increased V Mn content enhances the Ca 2+ and Mg 2+ adsorption properties of the birnessite coatings. When immersed in Ca 2+ /Mg 2+ aqueous solution, the birnessite coatings significantly promote fibronectin adsorption and the exposure of cell‐binding domains on adsorbed fibronectin with 5M120‐Ti showing the greatest enhancement. Accordingly, the 5M120‐Ti surface provides more α 5 β 1 ‐integrin‐specific instructions to MC3T3‐E1 preosteoblasts capable of enhancing spreading and osteoblastic differentiation compared to two other samples. This study may provide a prospective approach of modulation of integrin–ligand interactions for controlling cell behavior by adjusting metal vacancies in metal oxides coatings.