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Substrate Independent Liquid Phase Epitaxy of HKUST‐1 as Anticoagulant and Antimicrobial Coating
Author(s) -
Zhang Yu,
Zhao Qian,
Li Weijie,
Liu Junfeng,
Chen Junying,
Fan Yonghong,
Weng Yajun
Publication year - 2020
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201902011
Subject(s) - materials science , biocompatibility , surface modification , chemical engineering , coating , substrate (aquarium) , nucleation , titanium , nanotechnology , metallurgy , organic chemistry , chemistry , oceanography , geology , engineering
Abstract The effective deposition of metal–organic frameworks on kinds of biomaterials is still challenging and highly desirable. Using polydopamine as the effective nucleation center, HKUST‐1 is successfully prepared on three kinds of inert biomaterials, i.e., titanium oxide film (Ti–O), 316L stainless steel (316L SS), and poly(vinyl chloride) (PVC). Characterization of the surfaces by powder X‐ray diffraction confirm the oriented crystal growth of HKUST‐1 on the polydopamine coated substrates. There are no significant difference in catalytical NO generation and surface copper content of the three samples with HKUST‐1 deposition. All keep a NO release speed of ≈2.5 × 10 −10 mol cm −2 min −1 , thus platelet activation on the HKUST‐1 modified surfaces are inhibited compared to that of the unmodified ones. Ex vivo test shows thrombi formation is dramatically reduced. The HKUST‐1 coated surfaces elicit 95% reduction in the bacterial attachment of both Staphylococcus aureus and Escherichia coli . The endothelial cells and macrophages culture results support good biocompatibility of the modified surfaces. It provides a promising, facile, and effective approach for surface modification of blood contact biomaterials.