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Unique Role of Arginine in Positively‐Charged Surface for Promotion of Antibacterial and Osteogenetic Capabilities
Author(s) -
Zhang Wei,
Liu Jun,
Yang Kun,
Qu Wei,
Liu Ke,
Liu Na,
Gu Bin,
Hu Nan,
Ji Junhui,
Chu Paul K.,
Wang Huaiyu
Publication year - 2019
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201901414
Subject(s) - arginine , materials science , coating , antibacterial activity , in vivo , cationic polymerization , titanium , hydrochloride , bacteria , surface modification , chemical engineering , nanotechnology , amino acid , biomedical engineering , biochemistry , chemistry , polymer chemistry , metallurgy , biology , medicine , microbiology and biotechnology , engineering , genetics
Orthopedic implants made of titanium and titanium alloys are vulnerable to invasion of pathogenic bacteria and hence, it is desirable to endow implants with the antibacterial capability to mitigate postsurgical infection and other undesirable side‐effects. In this study, arginine is combined with polyhexamethylene biguaidine hydrochloride (PHMB) to fabricate an antibacterial coating on titanium samples. As arginine with the guanidinium form is similar to PHMB, the coating is positively‐charged and delivers excellent antibacterial performance due to the high surface potential. Furthermore, arginine is a natural α‐amino acid being friendlier to tissues than PHMB and the coating delivers good osteogenetic performance in vitro and in vivo in addition to a low level of inflammatory response. The combination of cationic arginine and PHMB enhances the antibacterial and osteogenetic functions simultaneously and suggests clinical potential.