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Directing Mesenchymal Stem Cells with Gold Nanowire Arrays
Author(s) -
Zhou Qihui,
Zhao Zhiyuan,
Zhou Ziwei,
Zhang Gang,
Chiechi Ryan C.,
van Rijn Patrick
Publication year - 2018
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201800334
Subject(s) - nanotopography , biointerface , materials science , nanowire , nanotechnology , nanoscopic scale , mesenchymal stem cell , cell adhesion , adhesion , composite material , microbiology and biotechnology , biology
Controlling cell organization is still a major bottleneck in biointerface engineering when the material dimensions decrease to the nanoscale. Here, Au nanowire‐patterned array platforms with multiscale design from the macroscale to the nanoscale are developed for studying human bone marrow–derived mesenchymal stem cell (hBM‐MSC) response. When the angle of the Au nanowires on glass is increased from 0° to 90°, hBM‐MSC arrangement exhibits a transition from a unidirectional distribution induced by a vector response to a bimodal polarization pattern. The degree of cell vector response and elongation decreases with increasing nanowire angles from 0° to 90°. Further, it is demonstrated that the specific cell adhesion and organization are dependent on the surface micro/nanotopography, which is greatly enhanced by introducing stem cell‐material affinity differences. An ideal model and new insights into a deeper understanding of cell–nano‐biointerface interactions are provided.