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Self‐Healing Biomaterials: From Molecular Concepts to Clinical Applications
Author(s) -
Diba Mani,
Spaans Sergio,
Ning Ke,
Ippel Bastiaan D.,
Yang Fang,
Loomans Bas,
Dankers Patricia Y. W.,
Leeuwenburgh Sander C. G.
Publication year - 2018
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201800118
Subject(s) - biomaterial , self healing , materials science , self healing hydrogels , nanotechnology , tissue engineering , self healing material , regenerative medicine , biomedical engineering , engineering , medicine , chemistry , biochemistry , alternative medicine , pathology , polymer chemistry , cell
Biomaterials are being applied in increasingly complex areas such as tissue engineering, bioprinting, and regenerative medicine. For these applications, challenging—or even contradictory—combinations of biomaterial properties are often required which cannot be met by conventional biomaterials. During the past decade, several new concepts have been developed to render biomaterials self‐healing, thereby offering new opportunities to improve the functionality of traditional biomaterials in terms of their mechanical, handling, and biological properties. Consequently, various types of self‐healing polymeric, ceramic, or composite biomaterials have been developed. Nevertheless, despite the rapid emergence of the field of self‐healing biomaterials, this field of research has not been reviewed during the recent years. Therefore, this article provides a critical overview of recent progress in the field of self‐healing biomaterials research by discussing both extrinsic and intrinsic self‐healing systems. While the extrinsic self‐healing section focuses on self‐healing dental materials and orthopedic bone cements that rely on release of healing liquids from embedded microcapsules, the section on intrinsic self‐healing materials mainly discusses concepts for self‐healing of polymeric biomaterials that are either hydrated (hydrogels) or nonhydrated (e.g., films and coatings). Finally, benefits of the self‐healing feature for biomaterials are discussed, and directions for future research and developments are outlined.