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Biomimetic Surface Engineering of Biomaterials by Using Recombinant Mussel Adhesive Proteins
Author(s) -
Jo Yun Kee,
Kim Hyo Jeong,
Jeong Yeonsu,
Joo Kye Il,
Cha Hyung Joon
Publication year - 2018
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201800068
Subject(s) - surface engineering , biomolecule , tissue engineering , materials science , nanotechnology , surface modification , protein engineering , recombinant dna , adhesive , molecular engineering , biomedical engineering , chemistry , chemical engineering , engineering , biochemistry , enzyme , layer (electronics) , gene
Surface engineering is a key approach for tailoring new functionalities into biomaterials to achieve better clinical performance. The rise of genetic engineering and molecular biotechnology made it possible to design artificial sticky proteins derived from marine mussels that are capable of firmly anchoring on a variety of substrates with high binding strength, opening a new route for surface engineering of biomaterials. Coatings of recombinant mussel adhesive proteins (MAPs) have aroused great interest for the surface functionalization of biomaterials due to their simplicity, versatility, and high stability under physiological conditions, as well as their favorable interactions with cells. In addition, recombinant MAPs can be engineered to provide desired specific functionalities on target surfaces by genetic fusion with functional peptides and/or by the immobilization of biomolecules. This review provides an overview of recombinant MAPs‐based surface coatings, highlighting their mechanisms, characteristic surface properties, and diverse applications in providing bioengineered surfaces in the fields of biomedical and tissue engineering.