Premium
Fabrication of Pyrrole‐Based Electrochemical Biosensor Platform Using Nanoimprint Lithography
Author(s) -
Ahn Junhyoung,
Kwon Soongeun,
Jung Sanghee,
Lee Wang Sik,
Jeong Jinyoung,
Lim Hyungjun,
Shin YongBeom,
Lee JaeJong
Publication year - 2018
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201701593
Subject(s) - nanoimprint lithography , materials science , biosensor , electrode , nanotechnology , polydimethylsiloxane , working electrode , cyclic voltammetry , soft lithography , nanostructure , fabrication , lithography , nanomesh , electrochemistry , optoelectronics , graphene , chemistry , medicine , alternative medicine , pathology
Many electrochemical biosensors are developed and widely used for the detection of biological responses. However, there is a limitation like increasing the surface area of the working electrode for the improvement of sensitivity. Nanoimprint lithography (NIL) is a simple method that uses stamp and UV or thermally curable resins for fabricating nanopatterns and nanostructures at low cost and with high throughput and high resolution. Therefore, the fabrication of a nanostructure on the working electrode using nanoimprint lithography can improve not only the sensitivity of a biosensor to biological responses by increasing the surface area of the working electrode but also the mass production of nanopatterned electrodes. Here, a conducting polymer‐based UV‐curable resin is aimed to develop and to use it to fabricate a uniform nanostructure on the working electrode. The 150 nm pillar patterns on a Pt electrode are created using polydimethylsiloxane stamps and KIMM ANT‐6HO UV‐NIL system and measured electrochemical signals using cyclic voltammetry. Furthermore, glucose oxidase is immobilized on the conducting polymer‐imprinted electrode. The developed electrochemical biosensor successfully measures glucose levels across a dynamic range of 0.1 µg mL −1 to 200 mg mL −1 under optimized conditions.