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Synergistic Exploitation of the Superoxide Scavenger Properties of Reduced Graphene Oxide and a Trityl Organic Radical for the Impedimetric Sensing of Xanthine
Author(s) -
Seber Gonca,
Muñoz Jose,
Sandoval Stefania,
Rovira Concepció,
Tobias Gerard,
MasTorrent Marta,
Crivillers Núria
Publication year - 2018
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201701072
Subject(s) - graphene , xanthine , xanthine oxidase , radical , oxide , superoxide , materials science , electrochemistry , hydroxyl radical , covalent bond , electrode , inorganic chemistry , scavenger , photochemistry , chemistry , nanotechnology , organic chemistry , enzyme , metallurgy
This work is based on synergetically exploiting the activity of graphene‐based materials and trityl free radicals to sense xanthine (X) by their combined scavenging properties for superoxide anion radical (O 2 •− ). For this, reduced graphene oxide (rGO) and rGO covalently functionalized with a perchlorotriphenylmethyl (PTM) radical derivative (rGO@PTM) are synthesized, characterized, and casted on an electrode surface to achieve a highly sensitive electrochemical recognition platform for xanthine determination. The electrochemical analysis is based on impedimetrically monitoring a radical‐involved reaction on the graphene‐based electrode surface after reacting with such O 2 •− derived from the xanthine/xanthine oxidase enzymatic system. The presented strategy yields to determine X at n m levels, decreasing the detection limit 100 times with respect to previously reported (bio)sensors.