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Optical Biosensors Based on Nitrogen‐Doped Graphene Functionalized with Magnetic Nanoparticles
Author(s) -
Zhang Wenjing,
Chen Chaopeng,
Yang Dongxu,
Dong Gongxian,
Jia Shujuan,
Zhao Bingxin,
Yan Lu,
Yao Qingqing,
Sunna Anwar,
Liu Yong
Publication year - 2016
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201600590
Subject(s) - detection limit , glucose oxidase , biosensor , graphene , hydrogen peroxide , nuclear chemistry , materials science , abts , nanoparticle , catalysis , nanocomposite , inorganic chemistry , chemistry , nanotechnology , chromatography , organic chemistry , dpph , antioxidant
Nanocomposites from nitrogen‐doped graphene (NG) and magnetic nanoparticles (MNPs) are prepared via an edge‐functionalized ball milling approach, followed by a coprecipitation method. Catalytic peroxidase‐like activity of the resulting MNP/NG is investigated. The as‐synthesized MNP/NG nanocomposites are used to catalyze the colorimetric reaction between hydrogen peroxide (H 2 O 2 ) and 2,2′‐azino‐bis(3‐ethylbenzo‐thiazoline‐6‐sulfonic acid) diammonium salt (ABTS). Typical absorption peaks associated with the oxidation of ABTS are found to increase linearly with increasing H 2 O 2 concentrations up to 10.0 × 10 −3 m with a detection limit of 17.1 × 10 −6 m . Rapid detection of H 2 O 2 with the use of MNP/NG is confirmed further by a glucose biosensor. Concentrations of glucose could be monitored by detection of H 2 O 2 since H 2 O 2 is generated during oxidation of glucose by glucose oxidase (GOx). The absorption intensity increases significantly with increasing glucose amounts up to 18.0 × 10 −3 m glucose, with a detection limit of 59.7 × 10 −6 m , indicating a high performance for glucose detection.