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Biointerfaces: Anisotropic Crystalline Protein Nanolayers as Multi‐Functional Biointerface for Patterned Co‐Cultures of Adherent and Non‐Adherent Cells in Microfluidic Devices (Adv. Mater. Interfaces 1/2015)
Author(s) -
Rothbauer Mario,
Ertl Peter,
Theiler Barbara A.,
Schlager Magdalena,
Sleytr Uwe B.,
Küpcü Seta
Publication year - 2015
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201570006
Subject(s) - biointerface , materials science , microfluidics , nanotechnology , biomolecule , layer (electronics) , microfluidic chip
In article 1400309, Ertl and co‐workers exploit the self‐assembly properties of various bacterial surface layer (S‐layer) proteins to readily fabricate an anisotropic multi‐functional nanobiointerface within microfluidic devices. S‐layer proteins with cell‐adhesive (rSbsB) and cell‐repellant (SbpA), as well as biomolecule‐binding capabilities (rSbpA/ZZ) are re‐assembled within microchannels for on‐chip patterning of co‐cultures of mobile with adherent cell types in order to generate multi‐functional surface properties.