Premium
Chiral Biomaterials: From Molecular Design to Regenerative Medicine
Author(s) -
Green David W.,
Lee JongMin,
Kim EunJung,
Lee DongJoon,
Jung HanSung
Publication year - 2016
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201500411
Subject(s) - chirality (physics) , nanotechnology , regenerative medicine , biomimetics , biomolecule , materials science , supramolecular chemistry , supramolecular chirality , design elements and principles , stem cell , chemistry , computer science , molecule , biology , physics , chiral symmetry breaking , microbiology and biotechnology , organic chemistry , quantum mechanics , software engineering , nambu–jona lasinio model , quark
Chirality is integral to biological complexity. Chiral biomolecules are central to all fundamental recognition, conformational and replication functions in biological systems. Chirality also exists in living cells and higher order biological structures. Less is known about the cellular interactions with chirality, although most living cells are imprinted with chiral‐based signatures. The harnessing of molecular, supramolecular, and structural chirality has been largely overlooked in biomaterials chemistry and the engineering of biological structures for regenerative medicine. Since chirality is a fundamental element of biological architecture its implementation in materials biomimicry is a necessity for mechanical, structural, and biological reasons. Take the latter, new investigations show the direct influence of biomimetic chiral patterning and chiral‐based architecture on stem cell activities and behavior. Biomimetic integration of chirality signatures into medical biomaterials provides a new capability to maximize biological function and compatibility especially for morphogenesis and regeneration.