Premium
Coating Engineering of MnFe 2 O 4 Nanoparticles with Superhigh T 2 Relaxivity and Efficient Cellular Uptake for Highly Sensitive Magnetic Resonance Imaging
Author(s) -
Liu Xiao Li,
Wang Yu Tong,
Ng Cheng Teng,
Wang Rong,
Jing Guang Yin,
Yi Jia Bao,
Yang Jian,
Bay Boon Huat,
Yung LinYue Lanry,
Fan Dai Di,
Ding Jun,
Fan Hai Ming
Publication year - 2014
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201300069
Subject(s) - materials science , superparamagnetism , nanoparticle , coating , magnetic resonance imaging , magnetic nanoparticles , nuclear magnetic resonance , nanotechnology , magnetization , magnetic field , medicine , physics , quantum mechanics , radiology
Superparamagnetic nanoparticles with superhigh T 2 relaxivity and cellular uptake are strongly desired for ultrasensitive magnetic resonance imaging (MRI). Towards this end, highly monodispersed manganese ferrite nanoparticles (MNPs, 6 nm) with mPEG‐ g ‐PEI and PEG coatings as model system are employed in this study to investigate the coating engineering for simultaneously high T 2 relaxivity and cellular uptake. The quantitative evaluations of the intracellular uptake indicate that mPEG‐ g ‐PEI modified MNPs possess highly efficient cellular uptake, 2.4‐fold larger than that with mPEG coating. More significantly, this coating simultaneously leads to a remarkably high T 2 relaxivity up to 331.8 m m −1 s −1 , which is 4 times larger than that of the mPEG control and the largest value reported for superparamagnetic iron oxides with similar size. Modeling analysis reveals that the superior relaxivity is mainly attributed to the largely reduced diffusivity of water molecules trapped in the mPEG‐ g ‐PEI net. Further MRI of MDA‐MB‐231 breast cancer cells loaded MNPs with mPEG‐ g ‐PEI coating demonstrated the strong MR contrast in vitro effect with a T 2 relaxivity as high as 92.6 m m −1 s −1 , 2.5‐folds larger than reported 10 nm MNPs. This study provides a universal strategy of coating engineering of various magnetic nanoparticles for highly sensitive MRI.