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Development of a Protein Mimic with Peptide Ligands to Enhance Specific Sensing and Targeting by the Zwitterionic Surface Engineering of Poly(amido amine) Dendrimers
Author(s) -
Wang Longgang,
Zhang Juan,
Lin Weifeng,
Wang Zhen,
Chen Shengfu
Publication year - 2014
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201300059
Subject(s) - dendrimer , rational design , amine gas treating , materials science , peptide , biocompatibility , nanotechnology , molecule , surface modification , combinatorial chemistry , selectivity , chemistry , organic chemistry , polymer chemistry , biochemistry , catalysis , metallurgy
A full layer of zwitterionic carboxybetaine‐modified G5 PAMAM with extra targeting c(RGDyK) motifs shows excellent biocompatibility and about 100 times higher efficacy than free c(RGDyK) motifs while high selectivity of c(RGDyK) is preserved. This work provides a rational method to design protein‐like molecules to obtain therapeutic function.