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Three‐Dimensional Graphene Composite Macroscopic Structures for Capture of Cancer Cells
Author(s) -
Yin Shengyan,
Wu YunLong,
Hu Benhui,
Wang Yu,
Cai Pingqiang,
Tan Chek Kun,
Qi Dianpeng,
Zheng Liyan,
Leow Wan Ru,
Tan Nguan Soon,
Wang Shutao,
Chen Xiaodong
Publication year - 2014
Publication title -
advanced materials interfaces
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.671
H-Index - 65
ISSN - 2196-7350
DOI - 10.1002/admi.201300043
Subject(s) - nanostructure , materials science , graphene , nanotechnology , circulating tumor cell , substrate (aquarium) , tumor cells , cancer , computer science , cancer research , medicine , biology , ecology , metastasis
A hierarchical nanostructured 3D platform is reported that combines microporosity with a nanostructure for selective capture of cancer cells. The microporosity allows red blood cells to travel through, while the anti‐EpCAM modified nanostructure captures circulating tumor cells. These systems allow for considerable increase in the contact frequency between target cells and the substrate, thus enhancing the cancer cell filtration and isolation efficiency.