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Production of Multiple Cell‐Laden Microtissue Spheroids with a Biomimetic Hepatic‐Lobule‐Like Structure (Adv. Mater. 36/2021)
Author(s) -
Hong Gyusik,
Kim Jin,
Oh Hyeongkwon,
Yun Seokhwan,
Kim Chul Min,
Jeong YunMi,
Yun WonSoo,
Shim JinHyung,
Jang Ilho,
Kim CYoon,
Jin Songwan
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202170286
Subject(s) - spheroid , regenerative medicine , materials science , microfluidics , nanotechnology , biomedical engineering , in vivo , microbiology and biotechnology , cell culture , stem cell , biology , engineering , genetics
Biomedical Applications In article number 2102624, Songwan Jin and co‐workers generate liver spheroids that resemble the in vivo structure of the lobules. The structural integrity is maintained for several days, engendering an increased performance of cellular function. This is achieved thanks to the combination of two cutting edge technologies: preset‐extrusion 3D bioprinting and microfluidics. Moreover, structured microtissues once injected into animals show a better engraftment, bringing to light the importance of phenotypically relevant models not only for drug screening but also regenerative medicine.