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Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening (Adv. Mater. 36/2021)
Author(s) -
Lin Weilin,
Gandhi Shanil,
Oviedo Lara Alan Rodrigo,
Thomas Alvin K.,
Helbig Ralf,
Zhang Yixin
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202170283
Subject(s) - wetting , materials science , amphiphile , coating , contact angle , in situ , nanotechnology , polar , chemical engineering , organic chemistry , composite material , copolymer , polymer , chemistry , physics , astronomy , engineering
Coatings In article number 2102349, Yixin Zhang and co‐workers report an amphiphilic coating for glass surfaces, on which small droplets of polar aprotic organic solvents can be deposited with an enhanced contact angle (small feature size) and inhibited motion (strong binding), permitting fully automated multiple rounds of combinatorial synthesis of small‐molecule compounds and peptides. The amphiphilic coating can be switched to hydrophilic network for protein‐ and cell‐based screening.