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Cancer Therapy: Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen‐Presenting Systems by Intracellular Hydrogelation (Adv. Mater. 30/2021)
Author(s) -
Lin JungChen,
Hsu ChungYao,
Chen JuiYi,
Fang ZihSyun,
Chen HuiWen,
Yao BingYu,
Shiau Gwo Harn M.,
Tsai JengShiang,
Gu Ming,
Jung Meiying,
Lee TongYoung,
Hu CheMing J.
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202170232
Subject(s) - modular design , intracellular , materials science , microbiology and biotechnology , cancer cell , cancer , cancer research , adoptive cell transfer , nanotechnology , medicine , immunology , biology , t cell , immune system , computer science , operating system
Robust and modular systems for T cell expansion have immense utilities for clinical development and immunoengineering research. In article 2101190, Che‐Ming J. Hu and co‐workers demonstrate a photoactivated intracellular radical polymerization technique that transforms live dendritic cells into a functional T‐cell‐stimulating biomaterial, which effectively enhances adoptive cell therapy against cancer in mice.