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Skeletal Muscle Regeneration: Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury (Adv. Mater. 14/2021)
Author(s) -
Jin Yoonhee,
Shahriari Dena,
Jeon Eun Je,
Park Seongjun,
Choi Yi Sun,
Back Jonghyeok,
Lee Hyungsuk,
Anikeeva Polina,
Cho SeungWoo
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202170104
Subject(s) - decellularization , skeletal muscle , regeneration (biology) , extracellular matrix , materials science , tissue engineering , biomedical engineering , progenitor cell , anatomy , microbiology and biotechnology , stem cell , biology , medicine
In article number 2007946, Polina Anikeeva, Seung‐Woo Cho, and co‐workers develop a hybrid muscle construct for skeletal muscle regeneration using synthetic polymer scaffolds engineered with decellularized muscle extracellular matrix and induced skeletal myogenic progenitor cells. Thermally drawn fiber scaffolds modified with muscle extracellular matrix provide the optimal mechani cal robustness and biochemical cues for reprogrammed muscle tissue. Engraftment of the bioengineered muscle construct induces de novo muscle regeneration and functional recovery.