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Cancer Immunotherapy: Reprogramming the Tumor Microenvironment through Second‐Near‐Infrared‐Window Photothermal Genome Editing of PD‐L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy (Adv. Mater. 12/2021)
Author(s) -
Tang Honglin,
Xu Xiaojie,
Chen Yuxuan,
Xin Huhu,
Wan Tao,
Li Bowen,
Pan Hongming,
Li Da,
Ping Yuan
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202170086
Subject(s) - reprogramming , photothermal therapy , cancer immunotherapy , immunotherapy , nanorod , tumor microenvironment , genome editing , materials science , photothermal effect , cancer research , cancer , nanotechnology , crispr , biology , tumor cells , cell , genetics , gene
In article number 2006003, Yuan Ping and co‐workers, by means of photothermal transcription of CRISPR/Cas9 in the second near‐infrared window, demonstrate genome editing of PD‐L1 to be effective to reprogram the tumor microenvironment. The photothermal genome editing for the disruption of PD‐L1 mediated by supramolecular gold nanorods also simultaneously activates T cells to infiltrate and attack tumor cells in the deep tissues, which can substantially improve cancer immunotherapy.