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Cancer Therapy: Nanoassemblies with Effective Serum Tolerance Capability Achieving Robust Gene Silencing Efficacy for Breast Cancer Gene Therapy (Adv. Mater. 7/2021)
Author(s) -
Liu Hongmei,
Liu Chongyi,
Ye Li,
Ma Ding,
He Xiaozhen,
Tang Qianyun,
Zhao Xue,
Zou Hanbing,
Chen Xiaojing,
Liu Peifeng
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202170052
Subject(s) - gene silencing , cancer , materials science , transfection , genetic enhancement , in vivo , cancer research , breast cancer , gene , nanotechnology , medicine , biology , biochemistry , genetics
Nanoassemblies for cancer gene therapy are designed by Peifeng Liu and co‐workers, as described in article number 2003523, with enhanced serum resistance and robust siRNA transfection efficiency in serum. In vivo, the nanoassemblies, with high stabilities in serum, protect siRNA from degradation and reach tumor sites efficiently.