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Near‐Infrared‐Light Remote‐Controlled Activation of Cancer Immunotherapy Using Photothermal Conjugated Polymer Nanoparticles
Author(s) -
Fu Xuancheng,
Huang Yiming,
Zhao Hao,
Zhang Endong,
Shen Qi,
Di Yufei,
Lv Fengting,
Liu Libing,
Wang Shu
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202102570
Subject(s) - immunotherapy , cancer immunotherapy , materials science , photothermal therapy , cancer cell , cancer research , conjugated system , photothermal effect , cancer , nanotechnology , biology , polymer , genetics , composite material
Remote control of the therapeutic process is an ideal strategy for maximizing efficacy and avoiding side effects, especially for cancer immunotherapy. Herein, a conjugated polymer nanoparticles (CPNs)‐mediated optogenetic system for in situ activation of immunotherapy under near‐infrared laser irradiation is reported. This system is composed of photothermal CPNs and interferon‐gamma (IFN‐γ) plasmid driven by heat shock promoter HSP70. The photothermally responsive CPNs serve as a photo–heat nanotransducer to trigger the gene transcription of IFN‐γ cytokine. The secreted IFN‐γ from cancer cells can sufficiently elicit surrounding tumor‐associated macrophages activation through IFN‐γ‐JAK‐STAT1 transcription‐factor signaling pathway and finally induce cancer cell killing by immunotherapy. Therefore, this synergetic optogenetic system provides a promising approach to remotely control the process of cancer immunotherapy.