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An Oligonucleotide‐Distortion‐Responsive Organic Transistor for Platinum‐Drug‐Induced DNA‐Damage Detection
Author(s) -
Ye Dekai,
Wang Juan,
Shen Hongguang,
Feng Xinping,
Xiang Lanyi,
Jin Wenlong,
Zhao Wenrui,
Ding Jiamin,
He Zihan,
Zou Ye,
Meng Qing,
Cui Wei,
Zhang Fengjiao,
Di Chongan,
Fan Chunhai,
Zhu Daoben
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202100489
Subject(s) - materials science , transistor , dna damage , nanotechnology , dna , oligonucleotide , platinum , biosensor , chemistry , biochemistry , voltage , catalysis , physics , quantum mechanics
Organic transistor with DNA‐damage evaluation ability can open up novel opportunities for bioelectronic devices. Even though trace amounts of drugs can cause cumulative gene damage in vivo, the extremely low occurrence proportion makes them hardly transduced into detectable electric signals. Here, an ultrasensitive DNA‐damage sensor based on an oligonucleotide‐distortion‐responsive organic transistor (DROT) is reported by creating controllable conformation change of double‐stranded DNA on the surface of organic semiconductors. In combination with interfacial charge redistribution and efficient signal amplification, the DROT provides an ultrasensitive single‐site DNA‐damage response with 20.5 s even upon 1 × 10 −12 m cisplatin. The high generalizability of this DROT to three generations of classical platinum drugs and gene‐relevant DNA damage is demonstrated. A biochip is further designed for intelligent damage analysis in complex environments, which holds the potential for high‐throughput biotoxicity evaluation and drug screening in the future.