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Localized Delivery of Theranostic Nanoparticles and High‐Energy Photons using Microneedles‐on‐Bioelectronics
Author(s) -
Lee Youngsik,
Kang Taegyu,
Cho Hye Rim,
Lee Gil Ju,
Park Ok Kyu,
Kim Sangyeon,
Lee Bowon,
Kim Hyun Myung,
Cha Gi Doo,
Shin Yoonsoo,
Lee Wanghee,
Kim Minjeong,
Kim Hyunjoong,
Song Young Min,
Choi Seung Hong,
Hyeon Taeghwan,
Kim DaeHyeong
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202100425
Subject(s) - bioelectronics , materials science , nanotechnology , drug delivery , nanoparticle , photon , biosensor , optics , physics
The low delivery efficiency of light‐responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood–brain barrier, has been a critical issue in NP‐based cancer treatments. Furthermore, high‐energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high‐energy photons to the target tumor using microneedles‐on‐bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light‐guiding/spreading microneedles deliver high‐energy photons from bioelectronics to the NPs. The high‐energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo‐drugs. The proposed method is demonstrated with mouse tumor models in vivo.