Premium
Cancer Immunotherapy: Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy (Adv. Mater. 47/2020)
Author(s) -
Qing Shuang,
Lyu Chengliang,
Zhu Li,
Pan Chao,
Wang Shuang,
Li Feng,
Wang Jianghua,
Yue Hua,
Gao Xiaoyong,
Jia Rongrong,
Wei Wei,
Ma Guanghui
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070350
Subject(s) - tumor microenvironment , reprogramming , immunotherapy , materials science , bacterial outer membrane , cancer immunotherapy , cancer research , vesicle , nanotechnology , membrane , immune system , tumor cells , cell , biology , escherichia coli , immunology , biochemistry , gene
In article number 2002085, Wei Wei, Guanghui Ma, and co‐workers develop an outer membrane vesicle (OMV)‐based platform for tumor immunotherapy. After demonstrating OMVs from Escherichia coli BL21 have a strong ability for reprogramming the tumor microenvironment (TME), calcium phosphate shells are employed to cover the OMV surface. Such a “shielding” strategy not only enables the safe use of the OMVs via intravenous injection, but also brings an additional functionality of neutralizing the acidic TME. Moreover, the outer shells can also be integrated with functional components to further enhance the therapeutic effect for highly intractable tumors.