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Spinal‐Cord Injury Treatment: Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid‐Nanoscaffold‐Based Therapeutic Interventions (Adv. Mater. 43/2020)
Author(s) -
Yang Letao,
Conley Brian M.,
Cerqueira Susana R.,
Pongkulapa Thanapat,
Wang Shenqiang,
Lee Jae K.,
Lee KiBum
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070325
Subject(s) - spinal cord injury , materials science , spinal cord , central nervous system , in vivo , inhibitory postsynaptic potential , medicine , biomedical engineering , biology , microbiology and biotechnology , psychiatry
Current treatment of central nervous system (CNS) injuries has been hampered by the neuroinhibitory microenvironment. In article number 2002578, Jae K. Lee, Ki‐Bum Lee, and co‐workers develop a method to effectively treat CNS injuries by delivering anti‐inflammatory drugs in vivo and providing a permissive neural matrix using biodegradable nanoscaffolds. Implantation of drug‐loaded nanoscaffolds to spinal‐cord injury sites reduces macrophage infiltration, suppresses fibrotic scarring, and thereby promotes functional recovery.