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COVID‐19 Vaccines: Particulate Alum via Pickering Emulsion for an Enhanced COVID‐19 Vaccine Adjuvant (Adv. Mater. 40/2020)
Author(s) -
Peng Sha,
Cao Fengqiang,
Xia Yufei,
Gao XiaoDong,
Dai Lianpan,
Yan Jinghua,
Ma Guanghui
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070303
Subject(s) - covid-19 , adjuvant , alum , pickering emulsion , virology , materials science , particulates , medicine , nanotechnology , immunology , nanoparticle , infectious disease (medical specialty) , biology , metallurgy , disease , pathology , ecology , outbreak
For enhanced COVID‐19 vaccines, in article number 2004210, Yufei Xia, Guanghui Ma, and co‐workers pack licensed alum on a squalene/water interphase. Thereby, this century‐old adjuvant “travels through time” in a new form of alum‐stabilized Pickering emulsion (PAPE), which not only inherits the clinically acknowledged biosafety, but also demonstrates enhanced cellular uptake and cross‐presentation of antigens for potent humoral and cellular responses.