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Cancer Therapy: Selectively Suppressing Tumor Angiogenesis for Targeted Breast Cancer Therapy by Genetically Engineered Phage (Adv. Mater. 29/2020)
Author(s) -
Li Yan,
Qu Xuewei,
Cao Binrui,
Yang Tao,
Bao Qing,
Yue Hui,
Zhang Liwei,
Zhang Genwei,
Wang Lin,
Qiu Penghe,
Zhou Ningyun,
Yang Mingying,
Mao Chuanbin
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070214
Subject(s) - genetically engineered , angiogenesis , cancer research , cancer , cancer therapy , nanofiber , genetically modified organism , materials science , medicine , biology , nanotechnology , gene , biochemistry
Nontoxic phage virus nanofibers are genetically engineered by Mingying Yang, Chuanbin Mao, and co‐workers in article number 2001260 to first home to tumors through the blood circulation and then capture proteins that can promote blood vessel formation in the tumors. The phages are thus able to suppress tumor growth due to the inhibition of the tumor angiogenesis.