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Cancer Therapy: Harnessing the Formation of Natural Killer–Tumor Cell Immunological Synapses for Enhanced Therapeutic Effect in Solid Tumors (Adv. Mater. 22/2020)
Author(s) -
Im Sooseok,
Jang Donghyun,
Saravanakumar Gurusamy,
Lee Junseok,
Kang Yeoul,
Lee Yeong Mi,
Lee Jaehyun,
Doh Junsang,
Yang Zung Yoon,
Jang Myoung Ho,
Kim Won Jong
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070167
Subject(s) - extracellular matrix , drug delivery , materials science , cancer cell , cancer research , cell , cancer , tumor cells , nanotechnology , microbiology and biotechnology , biology , biochemistry , genetics
In article number 2000020, Won Jong Kim and co‐workers describe a reinforced natural killer (ReNK) system, adopting the formation of NK–tumor cell immunological synapses (IS) as a trigger for delivery of tumor‐specific chemotherapeutics. NK cells are decorated with the IS environment‐responsive micellar system to ensure the release of drug when they attack cancer cells. The strategy enables the NK cells to inhibit the growth of solid tumors by efficient penetration of the delivered drug into the tumor tissue; otherwise, its penetration is hindered by the dense extracellular matrix of the tumor tissue.